Information for healthcare professionals from market surveillance of medicinal products

Pharmacovigilance in the spotlight

Learning from adverse reaction reports – cases from pharmacovigilance
The purpose of this new section is to use real-life case reports from Switzerland as a reminder of possible side effects that professionals should be aware of in day-to-day clinical practice. The only way to protect patients against undesirable effects is to take account of and report medicinal product risks.

Latest contributions


Daptomycin and eosinophilic pneumonia

Eosinophilic pneumonia | daptomycin | antibiotics |  staphylococci | antibiotic resistance


Medicinal product interactions of Paxlovid (nirmatrelvir/ritonavir) with certain immunosuppressants

Paxlovid | CYP3A4 | inhibitors | tacrolimus | narrow therapeutic range | trazodone | ritonavir | nirmatrelvir | COVID-19


Oral methotrexate and risk of unintentional overdose due to medication errors

Methotrexate | overdose | pancytopenia | dose adjustment Rheumatoid arthritis | palliative therapy | stomatitis


Encephalitis/meningoencephalitis after vaccination against tick-borne encephalitis (TBE)

Vaccinations | tick-borne encephalitis (TBE) | basic immunisation | booster | Swiss vaccination plan


Oral contraceptives and depression

Hormonal contraceptives | depression | estradiol | dienogest


Hypotonic-hyporesponsive episode and basic immunisation in infants

infants | vaccinations | hypotonia | hyporesponsive episode | apathy | HHE | basic immunisation | Swiss vaccination plan


Parenteral iron products and hypophosphataemia

iron products | ferric carboxymaltose | parenteral iron | hypophosphataemia.


Tizanidine and clinically relevant interactions

Tizanidine | Sirdalud | pharmacokinetic interactions | drug interactions | muscle relaxant | antispasmodic agent | CYP1A2 inhibitors | fluvoxamine | ciprofloxacin


Betaseptic and burns

Betaseptic | skin disinfection | burn | propanol | ethanol | povidone-iodine


Combined hormonal contraceptives (CHC) and thromboembolic events

Contraceptive | venous thrombosis | pulmonary embolism | drospirenone | chlormadinone acetate


Metamizole and agranulocytosis

Novalgin | metamizole | agranulocytosis


Loperamide and intentional overdose

Loperamide | overdose | drug dependency | opiate withdrawal symptoms | QT interval


Drug-induced pancreatitis

Pancreatitis | Ozempic | semaglutide | Imurek | azathioprine | isotretinoin


Fluoroquinolones and tendon inflammation/ruptures

Fluoroquinolones | moxifloxacin | iprofloxacin | levofloxacin | tendon rupture | Achilles tendon


Amiodarone and hyperthyroidism

Hyperthyroidism | amiodarone | thyroiditis | iodine level

Swissmedic Vigilance-News

Topical aspects of medicinal product risk assessment
Twice a year, the Safety of Medicines Division reports on current topics relating to adverse reaction surveillance and the evaluation of safety signals. Swissmedic's "Vigilance News" appears twice a year as an online resource.

Current Editions


Swissmedic Vigilance News Edition 32

In this edition:

  • Paclitaxel-induced cystoid macular oedema
  • Chemotherapy-associated severe hypertriglyceridaemia
  • Spider-like skin reactions following bortezomib (Velcade®)
  • Potential increased risk of neurodevelopmental disorders (NDD) in children whose fathers were treated with valproate

Previous issues


Swissmedic Vigilance-News Edition 31

In this edition:

  • Pregnancy outcomes after GLP-1 agonist exposure in early pregnancy
  • Drug-induced pancreatitis
  • Febuxostat and azathioprine: a rare interaction
  • Kounis syndrome: a less familiar ADR
  • Statistical Review 2022


Swissmedic Vigilance-News Edition 30

In this edition:

  • Checkpoint inhibitors: pregnancy-related outcomes
  • JAK inhibitors: risk minimisation / dosage individualisation
  • COVID-19 vaccines: myocarditis in elderly patients / adverse reactions after vaccination with bivalent vaccines
  • Haemovigilance: incorrect blood component transfused and near misses


Vigilance-News Edition 29

In this edition:

  • Reports of urticaria after booster vaccination with Spikevax
  • Contrast-induced neurotoxicity
  • Swiss Haemovigilance System: Regulatory aspects and transfusion reactions
  • Statistical Review 2021: Pharmacovigilance for human medicinal products, vaccinovigilance, vigilance for veterinary medicinal products


Vigilance-News Edition 28

In this edition:

COVID-19 immunisation:

  • Modification of the Information for healthcare professionals since authorisation
  • Myocarditis, thromboembolic events, multiple sclerosis
  • Persistent headache
  • Methods of signal detection / ”Observed versus expected” analyses


Vigilance-News Edition 27

In this edition:

COVID-19 immunisation:

  • Myocarditis/pericarditis: Case reports received by Swissmedic
  • Menstrual disorders – facts, possible causes, unanswered questions
  • Recent study findings and recommendations
    for vaccination of pregnant women
  • International cooperation
    in the area of pharmacovigilance


Vigilance-News Edition 26

In this edition:

  • COVID-19 vaccines: reporting suspected side effects correctly
  • Case report “COVID arm”
  • AEFI after immunisation with COVID-19 vaccines: Herpes zoster, neuralgic amyotrophy, immune thrombocytopenia

All issues