Information for medical professionals from market surveillance of medicinal products

Pharmacovigilance in the spotlight

Learning from adverse reaction reports – cases from pharmacovigilance
The purpose of this new section is to use real-life case reports from Switzerland as a reminder of possible side effects that professionals should be aware of in day-to-day clinical practice. The only way to protect patients against undesirable effects is to take account of and report medicinal product risks.

Latest contributions


Parenteral iron products and hypophosphataemia

iron products | ferric carboxymaltose | parenteral iron | hypophosphataemia.


Tizanidine and clinically relevant interactions

Tizanidine | Sirdalud | pharmacokinetic interactions | drug interactions | muscle relaxant | antispasmodic agent | CYP1A2 inhibitors | fluvoxamine | ciprofloxacin


Betaseptic and burns

Betaseptic | skin disinfection | burn | propanol | ethanol | povidone-iodine


Combined hormonal contraceptives (CHC) and thromboembolic events

Contraceptive | venous thrombosis | pulmonary embolism | drospirenone | chlormadinone acetate


Metamizole and agranulocytosis

Novalgin | metamizole | agranulocytosis


Loperamide and intentional overdose

Loperamide | overdose | drug dependency | opiate withdrawal symptoms | QT interval


Drug-induced pancreatitis

Pancreatitis | Ozempic | semaglutide | Imurek | azathioprine | isotretinoin


Fluoroquinolones and tendon inflammation/ruptures

Fluoroquinolones | moxifloxacin | iprofloxacin | levofloxacin | tendon rupture | Achilles tendon


Amiodarone and hyperthyroidism

Hyperthyroidism | amiodarone | thyroiditis | iodine level

Swissmedic Vigilance-News

Topical aspects of medicinal product risk assessment
Twice a year, the Safety of Medicines Division reports on current topics relating to adverse reaction surveillance and the evaluation of safety signals. Swissmedic's "Vigilance News" appears twice a year as an online resource.

Current Editions


Swissmedic Vigilance-News Edition 30

In this edition:

  • Checkpoint inhibitors: pregnancy-related outcomes
  • JAK inhibitors: risk minimisation / dosage individualisation
  • COVID-19 vaccines: myocarditis in elderly patients / adverse reactions after vaccination with bivalent vaccines
  • Haemovigilance: incorrect blood component transfused and near misses

Previous issues


Vigilance-News Edition 29

In this edition:

  • Reports of urticaria after booster vaccination with Spikevax
  • Contrast-induced neurotoxicity
  • Swiss Haemovigilance System: Regulatory aspects and transfusion reactions
  • Statistical Review 2021: Pharmacovigilance for human medicinal products, vaccinovigilance, vigilance for veterinary medicinal products


Vigilance-News Edition 28

In this edition:

COVID-19 immunisation:

  • Modification of the Information for healthcare professionals since authorisation
  • Myocarditis, thromboembolic events, multiple sclerosis
  • Persistent headache
  • Methods of signal detection / ”Observed versus expected” analyses


Vigilance-News Edition 27

In this edition:

COVID-19 immunisation:

  • Myocarditis/pericarditis: Case reports received by Swissmedic
  • Menstrual disorders – facts, possible causes, unanswered questions
  • Recent study findings and recommendations
    for vaccination of pregnant women
  • International cooperation
    in the area of pharmacovigilance


Vigilance-News Edition 26

In this edition:

  • COVID-19 vaccines: reporting suspected side effects correctly
  • Case report “COVID arm”
  • AEFI after immunisation with COVID-19 vaccines: Herpes zoster, neuralgic amyotrophy, immune thrombocytopenia

All issues