Updating of Annex 7 TPLRO – Revised list of variations

A revised list of variations according to Articles 21-24 TPO comes into force on 1 February 2026

06.01.2025

The lists published by Swissmedic, incl. Annex 7 of the Therapeutic Products Licensing Requirements Ordinance (TPLRO; SR 812.212.22) have been revised and amended. A need for revision, particularly of Annex 7 TPLRO, was identified on the basis of the collected reports and in keeping with the requirements and specifications of EU legislation. This annex has been harmonised as far as possible with the EU list of variations. The form Variations and extensions HMP has been amended accordingly on this basis. While the form comes into force on 1 February 2026, it can be viewed now via the link below.

Up until 31 January 2026, variations and extensions for human medicinal products must be submitted using the existing form (valid until 31 January 2026) and, from 1 February, using the new form (valid from 1 February 2026).

Any questions regarding the new Variations and extensions HMP form can be submitted via this link General information.

Related documents

ZL300_00_003e_FO Form Variations and extensions HAM (DOCX, 707 kB, 01.02.2025)valid until 31 January 2026 and for the correction of applications received by Swissmedic until 31 January 2026